Coverart for item
The Resource The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg

The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg

Label
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level
Title
The Philadelphia chromosome
Title remainder
a mutant gene and the quest to cure cancer at the genetic level
Statement of responsibility
Jessica Wapner ; foreword by Robert A. Weinberg
Creator
Contributor
Subject
Language
eng
Summary
This work focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec, " is the keynote of this astounding publication
Cataloging source
DNLM/DLC
http://library.link/vocab/creatorName
Wapner, Jessica
Dewey number
616.99/419042
Illustrations
  • illustrations
  • plates
Index
index present
LC call number
RC643
LC item number
.W36 2013
Literary form
non fiction
Nature of contents
bibliography
http://library.link/vocab/relatedWorkOrContributorDate
1942-
http://library.link/vocab/relatedWorkOrContributorName
Weinberg, Robert A.
http://library.link/vocab/subjectName
  • Chronic myeloid leukemia
  • Chronic myeloid leukemia
  • Cancer
  • Cancer
  • Mutation (Biology)
  • Imatinib
  • Hungerford, David S
Label
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 283-290) and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time
Control code
1414294
Dimensions
24 cm.
Extent
xiii, 303 pages, [8] pages of plates
Isbn
9781615190676
Isbn Type
(pbk.)
Lccn
2012047686
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations (some color)
System control number
  • (Sirsi) 1414294
  • (OCoLC)820450840
Label
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg
Publication
Bibliography note
Includes bibliographical references (p. 283-290) and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time
Control code
1414294
Dimensions
24 cm.
Extent
xiii, 303 pages, [8] pages of plates
Isbn
9781615190676
Isbn Type
(pbk.)
Lccn
2012047686
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations (some color)
System control number
  • (Sirsi) 1414294
  • (OCoLC)820450840

Library Locations

    • Stevens Memorial Library (North Andover)Borrow it
      345 Main Street, North Andover, MA, 01845, US
      42.6961299 -71.1263305
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